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2 edition of Clonidine use in intensive care unit patients found in the catalog.

Clonidine use in intensive care unit patients

Jennifer Fairbairn

Clonidine use in intensive care unit patients

a retrospective analysis

by Jennifer Fairbairn

  • 84 Want to read
  • 6 Currently reading

Published .
Written in English


Edition Notes

Ottawa Civic Hospital

The Physical Object
Pagination28 leaves
Number of Pages28
ID Numbers
Open LibraryOL19365839M

Clonidine transdermal patches are not to be used outside of the PICU setting for patients less than 8kg. They can be used in PICU at the discretion of the PICU consultant. If used for patients clonidine patch is to be removed at discharge from PICU and is . The investigators 24 subjects will be treated with 3 different doses of clonidine (, and µg/day), that is 8 per treatment arm. On top of this, 8 patients receiving no clonidine will serve as a reference group, in order to interpret hemodynamic and safety data, .

Formulation Immediate-release. Duration of Effect 3–5 hours. Initial Dose mg (Author’s recommendation). Maximum daily dose mx (divided). Available unit dose forms , , or mg tablets. Dosage Adjustments. Generally, the dose can be increased weekly by an amount equivalent to the starting dose (mg), to the optimal dose of the maximum dose of mg. α 2 ‐adrenoceptor agonists are well‐established as veterinary anesthetics but have only slowly entered human intensive care unit (ICU) and perioperative practice over the last 17 years. With many attractive properties in addition to sedation, including preservation of rousability, respiratory drive and airway reflexes at useful hypnotic doses, analgesia, anti‐inflammatory effects and.

  Buchheit J, Yeh D, Eikermann M, Lin H. Impact of Low-Dose Ketamine on the Usage of Continuous Opioid Infusion for the Treatment of Pain in Adult Mechanically Ventilated Patients in Surgical Intensive Care Units. J Intensive Care Med. January Clonidine, sold as the brand name Catapres among others, is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. It is used by mouth, by injection, or as a skin patch. Onset of action is typically within an hour with the effects on blood pressure.


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Clonidine use in intensive care unit patients by Jennifer Fairbairn Download PDF EPUB FB2

The total median clonidine exposure per intensive care unit day was mg/ICU day (interquartile range = –) in patients who discontinued dexmedetomidine within 8 h and mg/ICU day (interquartile range = –) (p = ) in patients who did by: 7. British Journal of Anaesthesia ; CLONIDINE IN THE TREATMENT OF ALCOHOL WITHDRAWAL IN THE INTENSIVE CARE UNIT P.

IP YAM, A. FORBES AND W. KOX SUMMARY We present two cases of patients with a past history of alcohol abuse admitted to the Intensive Care Unit (ICU) for treatment of respiratory problems, after multiple trauma and after sub Cited by: A lower temperature (°C) was observed in the clonidine group after adjustment for the time of follow‐up (P).

Our report is the first of its kind in humans that demonstrates possible antipyretic properties of enteral clonidine in the critically ill intensive care unit by: 1.

Clonidine Use in the Intensive Care Unit of a Tertiary Care Hospital: Retrospective Analysis Melanie Gillison, Jennifer Fairbairn, Kevin McDonald, Rosemary Zvonar, and Pierre Cardinal ABSTRACT Background: The a 2-adrenergic agonist clonidine may have beneficial effects in terms of analgesia and sedation for patients in the intensive care unit.

Clonidine is classified as an imidazoline and it is the prototypical alpha-2 receptor agonists. the supporting evidence for the use of this drug beyond its antihypertensive use in perioperative medicine and critical care in adults patients.

Keywords: Clonidine, alpha-2 Clonidine in Perioperative Medicine and Intensive Care Unit: More Cited by:   We enrolled 50 children. The median interquartile range (IQR) age was () years, and Pediatric Risk of Mortality score on pediatric intensive care unit admission was 12 (). In terms of feasibility outcomes, 90 Clonidine use in intensive care unit patients book of eligible patients were approached for consent, and on average, children were enrolled per month.

If the patient has been on clonidine for several days then reduction over 36 hours may be required. For low rates of infusion when weaning clonidine, less concentrated preparations may be used Ip Yam PC et al. Clonidine in the treatment of alcohol withdrawal in the intensive care unit.

Br J Anesthes ; Introduction. Critically ill ICU patients, particularly those on mechanical ventilation are exposed to anxiety, pain and stress ().Sedation, analgesia and delirium and their management are important aspects of care delivery in ICU with greater attention in recent years to research in sedation strategies, short term complications and longer term sequels (2, 3).Cited by: Integrated Critical Care Unit Guidelines for the use of Clonidine Infusion Background Clonidine is primarily a centrally acting alpha-2 agonist which reduces blood pressure and heart rate by reducing sympathetic discharge.

It also has sedative, analgesic and opioid sparing properties. Clinical indication • Hypertension (licensed). This systematic review and meta-analysis investigates the efficacy and safety of clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation.

We performed a comprehensive search of MEDLINE, EMBASE, CINAHL and the Cochrane trial registry. We identified RCTs that compared clonidine to any non-clonidine regimen in critically ill patients, excluding.

The total median clonidine exposure per intensive care unit day was mg/ICU day (interquartile range = –) in patients who discontinued dexmedetomidine within 8 h and mg/ICU day. Provision of adequate sedation is a fundamental part of caring for critically ill patients.

Propofol, dexmedetomidine, and benzodiazepines are the most commonly administered sedative medications for adult patients in the intensive care unit (ICU). These agents are limited by adverse effects, need fo.

Background: The α 2-adrenergic agonist clonidine may have beneficial effects in terms of analgesia and sedation for patients in the intensive care unit. Objective: To examine clonidine. Introduction. Clonidine hydrochloride is commonly used off‐label in paediatric anaesthesia and intensive care medicine.

It acts by reducing intraoperative anaesthetic requirements and metabolic responses to surgery due to its effects on central sympathetic outflow and centrally based analgesia mechanisms. 1 Clonidine is recommended for the sedation of critically ill children in Paediatric. The total median clonidine exposure per intensive care unit day was mg/ICU day (interquartile range = –) in patients who discontinued dexmedetomidine within 8 h and mg/ICU day (interquartile range = –) (p = ) in patients who did not.

We observed similar Richmond Agitation Sedation Scale and Confusion Assessment. This patient developed hypertension followed by hypotension, bradycardia, apnea, hallucinations, semi-coma, and premature ventricular contractions.

The patient fully recovered after intensive treatment. Plasma clonidine levels were 60 ng/mL after 1 hour, ng/mL after hours, ng/mL after 2 hours, and ng/mL after and hours. ABSTRACT. Background: The a2-adrenergic agonist clonidine may have beneficial effects in terms of analgesia and sedation for patients in the intensive care unit.

Objective: To examine clonidine prescribing practices in the intensive care unit of a tertiary care hospital and to determine the effect of this drug on requirements for analgesia and sedation.

Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in the intensive care unit (ICU) such as benzodiazepines and propofol are associated with significant unwanted effects.

Clonidine is an alpha-2 selective adrenergic agonist that may have a. This necessitates protracted weaning of DEX and longer length of stay in the pediatric intensive care unit (PICU) since DEX can only be administered as a continuous intravenous (IV) infusion.

CLON, on the other hand, has a longer half-life and has formulations that allow for continuous or intermittent IV and oral administration. Gillison M, Fairbairn J, McDonald K., Zvonar R, Cardinal P.

Clonidine use in the intensive care unit of a tertiary care hospital: Retrospective analysis. Can J Hosp Pharm ; Bohrer H, Bach A, Layer M, Werning P. Clonidine as a sedative adjunct in intensive care. Intensive Care Med ; 16/4: IP Yam PC, Forbes A.

CLONIDINE – FOR PAIN MANAGEMENT Dosing, Administration and Monitoring Guidelines Clinical documents related to this guideline • Intensive Care Unit – Clonidine Guideline Prescribing requirements and restrictions • Epidural Clonidine: should only prescribed and the first dose by an Anaesthetist or the Acute Pain Service (APS).Clonidine is an α 2-agonist, which is increasingly used as a sedative in both mechanically and spontaneously breathing patients.

It is particularly useful if agitation is a feature or after withdrawal of benzodiazepines or opioids. Economic evaluation of propofol for sedation of patients admitted to intensive care units.Pain is an unpleasant experience for all patients including intensive care patients; if it is not treated properly, it has deleterious effects on patients’ acute and chronic well-beings.

In ICU patients, it causes sympathetic stimulation leading to adverse hemodynamic effects and after discharge, these patients are at the higher risk for developing chronic pain and post-traumatic stress.